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Pancreasin 胰腺素: 胰腺表达的丝氨酸蛋白酶

人 胰腺素 : 290 AA， MW 31940Da
Signal sequence: 1-22, Pro-Pref-1: 23-34, Mature Pref-1: 35-290 
        10         20         30         40         50         60   
MRRPAAVPLL LLLCFGSQRA KAATACGRPR MLNRMVGGQD TQEGEWPWQV SIQRNGSHFC  
        70         80         90        100        110        120   
GGSLIAEQWV LTAAHCFRNT SETSLYQVLL GARQLVQPGP HAMYARVRQV ESNPLYQGTA     
       130        140        150        160        170        180   
SSADVALVEL EAPVPFTNYI LPVCLPDPSV IFETGMNCWV TGWGSPSEED LLPEPRILQK    
       190        200        210        220        230        240   
LAVPIIDTPK CNLLYSKDTE FGYQPKTIKN DMLCAGFEEG KKDACKGDSG GPLVCLVGQS  
       250        260        270        280        290   
WLQAGVISWG EGCARQNRPG VYIRVTAHHN WIHRIIPKLQ FQPARLGGQK
Swiss-Prot entry Q9BQR3;

 
Homology model of pancreasin. A model of the predicted pancreasin catalytic domain was generated starting from the crystallographically derived structure of human beta II-tryptase. The propeptide and the carboxyl-terminal 11?residues of pancreasin were omitted because they have no counterpart in the tryptase structure. In the model shown, the catalytic triad residues (His-75, Asp-124, Ser-229) in the active site are red, basic residues (lysine and arginine) are blue, acidic residues (aspartate and glutamate) are green, and predicted N-linked carbohydrate (CHO) attachment sites (Asn-55 and Asn-89) are cyan. Note that sugars (not shown) attached to Asn-55 and Asn-89 could influence access and binding of substrates in the active site. The ribbon structure shows side chains of the catalytic triad residues and putative N-linked asparagines. "Front" views show the active site face one, with the extended substrate-binding site oriented roughly vertically. "Side" views depict the active site binding cleft in profile, with the carbohydrate attachment sites to the left. The distribution of surface side chains of basic and acidic residues suggests patches of positive charge, despite an overall excess of residues with acidic side chains. J. Biol. Chem., Vol. 278, Issue 5, 3363-3371, January 31, 2003

 

试剂盒名称 人胰腺素(Pancreasin)酶联试剂盒
产品号 SK0007-01
规格 96 T
检测范围 31.2-2000 pg/mL
样本体积. 100 ul
样本类型 血清、血浆
正常值  
检测操作时间 4 hours
批内差异 <6.5%
批间差异 <8%

 
 
产品名称
目录号
规格
价格
人胰腺素(Pancreasin)酶联试剂盒
SK00007-01
96 T
3500
人胰腺素(Pancreasin)重组蛋白
00007-01-10
10 ug
3780
山羊抗人胰腺素(Pancreasin)抗体
A00007-01-100
100 ug
3780

 

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Dendrogram of pancreasins and related proteases. J. Biol. Chem., Vol. 278, Issue 5, 3363-3371, January 31, 2003
Blotting of tissue mRNA。 J. Biol. Chem., Vol. 278, Issue 5, 3363-3371, January 31, 2003
 

 

 


  
 
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