p53 Antibody

Transcription factors of the nuclear factor kappa B (NF-κB)/Rel family play a pivotal role in inflammatory and immune responses (1,2). There are five family members in mammals: RelA, c-Rel, RelB, NF-κB1 (p105/p50) and NF-κB2 (p100/p52). Both p105 and p100 are proteolytically processed by the proteasome to produce p50 and p52, respectively. Rel proteins bind p50 and p52 to form dimeric complexes that bind DNA and regulate transcription. In unstimulated cells, NF-κB is sequestered in the cytoplasm by IκB inhibitory proteins (3-5). NF-κB-activating agents can induce the phosphorylation of IκB proteins, targeting them for rapid degradation through an ubiquitin-proteasome pathway and releasing NF-κB to enter the nucleus where it regulates gene expression (6-8). NIK and IKKα (IKK1) regulate the phosphorylation and processing of NF-κB2 (p100) to produce p52, which is then translocated to the nucleus (9-11). Baeuerle, P.A. and Henkel, T. (1994) Annu Rev Immunol 12, 141-79. Baeuerle, P.A. and Baltimore, D. (1996) Cell 87, 13-20. Haskill, S. et al. (1991) Cell 65, 1281-9. Thompson, J.E. et al. (1995) Cell 80, 573-82. Whiteside, S.T. et al. (1997) EMBO J 16, 1413-26. Traenckner, E.B. et al. (1995) EMBO J 14, 2876-83. Scherer, D.C. et al. (1995) Proc Natl Acad Sci USA 92, 11259-63. Chen, Z.J. et al. (1996) Cell 84, 853-62. Senftleben, U. et al. (2001) Science 293, 1495-9. Coope, H.J. et al. (2002) EMBO J 21, 5375-85. Xiao, G. et al. (2001) Mol Cell 7, 401-9.   名称 人p53 ELISA试剂盒 监测范围 93.75 - 1500 pg/ml 灵敏度 10 pg/ml 样本体积 100 微升 样本种类 细胞上清, 血清, 尿 批内差异 5.4% 批间差异 10.0%       名称 人增生性细胞核抗原PCNA ELISA试剂盒 监测范围 1.875 - 30 U/ml 灵敏度 0.5 U/ml of PCNA 样本体积 100 微升 样本种类 Cell lysates, tissue culture media , serum, or plasma Unit Definition One unit (U) is defined as the amount of PCNA measured from ~ 2.6 x 103 SW620 cells. specificity human, mouse , rat 批内差异 5.4% 批间差异 10.0%   Anti-human p53 (NFKB2) antibody Flow cytometric analysis of HT-29 cells using p53 (7F5) Rabbit mAb (blue) compared to a nonspecific negative control antibody (red). Confocal Immunofluorescent analysis of HT-29 cells using p53 (7F5) Rabbit mAb (green). Actin filaments have been labeled with DY-554 phalloidin (red). Immunohistochemical analysis of paraffin-embedded human colon carcinoma, using p53 (7F5) Rabbit mAb. Immunohistochemical analysis of paraffin-embedded human breast carcinoma, using p53 (7F5) Rabbit mAb. Western blot analysis of extracts from 293 and COS cells, using p53 (7F5) Rabbit mAb.

产品名称	用途	目录号	规格	价格
人p53 ELISA试剂盒	血清、细胞上清、组织允浆	SK00036-04	96 T	6400
增生性细胞核抗原PCNA ELISA试剂盒	血清、细胞上清、血浆	SK00041-01	96 T	6400
兔抗人 p52 (NFKB2) 单克隆抗体	W IHC-P F	A00036-01-100	100 ug	询价
兔抗 p52 (NFKB2) 抗体	H M R Mk； W, IP	A00036-02-100	100 ug	询价
Phospho-NF-κB2 p100 (Ser866/870) Antibody #4810	H M (R) (B) (Dg); W, IP	A00036-03-100	100 ug	询价
兔抗p53 (7F5)单克隆抗体	H Mk；W IHC-P IF-IC F	A00036-04-100	100 ug	询价

 

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