Pentraxin 3 五聚素3 (PTX3)是一种长五聚素分子，也有人称之为肿瘤坏死因子刺激基因14 (TSG14)，由五个相同的亚单位组成长五聚体，分泌型的五聚素3 (PTX3)是一个45000道尔顿的糖蛋白。在机体炎症反应时含量升高，因而称为急性期反应蛋白。五聚素家族还包括C反应蛋白， 他是短的五聚素分子。C反应蛋白主要在肝脏合成。而五聚素3(PTX3)合成部位广泛，主要有颗粒性白细胞、脂肪细胞、内皮细胞、平滑肌细胞、成纤维细胞等。五聚素3(PTX3)具有多种生物学效应。可以结合多种可溶性受体配基参于免疫防御、女性生殖生育、动脉粥样硬化、细胞凋亡和血管再生的调节。爱迪博生物的研究人员关注于研究PTX3在代谢综合征中的生物学意义。日本学者2006年11月报告PTX3是不稳定心绞痛的早期标示物。它在急性冠状动脉综合征伴有血管损伤的临床检测意义值得关注。

Expression of pentraxin 3 (PTX3) in human atherosclerotic lesions

Pentraxin 3 (PTX3) and C-reactive protein (CRP) are members of the pentraxin superfamily. PTX3 expression is induced in response to inflammatory signals, and is produced at sites of inflammation by several types of cell, primarily monocytes/macrophages, dendritic cells (DCs), endothelial cells, smooth muscle cells (SMCs), and fibroblasts, but is not produced by hepatocytes, which are a major source of CRP. The aim of our study was to investigate the expression pattern of PTX3 in human atherosclerotic lesions using a novel monoclonal antibody against PTX3. We examined coronary arterial thrombi containing an atherosclerotic plaque component removed from patients with acute myocardial infarction and human aortic tissues with various degrees of atherosclerosis sampled from autopsy cases. Immunohistochemical study of paraffin and frozen sections indicated that macrophages, mainly foam cells, expressed PTX3 in advanced atherosclerotic lesions. Interestingly, we also clearly observed PTX3-positive neutrophils infiltrating into atherosclerotic plaques, suggesting that PTX3 derived from neutrophils as well as macrophages plays an important role in atherogenesis. J Pathol. 17 Dec., 2007

人的五聚素3 (PTX3)酶联免疫试剂盒可以检测血清或血浆的样本。肝素抗凝血可能影响检测结果。人五聚素3 (PTX3)酶联免疫试剂盒的灵敏度是30pg/ml. 样本体积20微升。正常水平在2纳克每毫升。检测疾病样本时样本可能需要稀释2-4倍。

小鼠五聚素3 (PTX3)酶联免疫试剂盒可以检测血清或血浆的样本。小鼠血清含量在 5.3 ~ 17 ng/ml; 灵敏度（Sensitivity of Mouse PTX3 ELISA）： 0.012 ng/ml,血清样本操作前需要4倍稀释；肝素可能影响检测结果。

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试剂盒名称

目录号

规格

价格

五聚素 3 (PTX3) （人）酶联免疫试剂盒

SK00101-01

96T

3590

五聚素 3 (PTX3) （人）酶联免疫试剂盒

SK00101-05

96T

6400

五聚素 3 (PTX3) （人), recombinant

001001-05

25ug

4095

五聚素 3 (PTX3) ( Mouse) 酶联免疫试剂盒

SK00101-02

96T

6500

五聚素 3 (PTX3) ( Mouse) 酶联免疫试剂盒

SK00101-03

96T

3590

C 反应蛋白(人)酶联免疫试剂盒

SK00080-01

96T

3400

抵抗素（人)酶联免疫试剂盒

SK00100-01

96T

2500