Oxidized low-density-lipoprotein receptor-1 (OLR-1)/Lectin-like oxidized low-density-lipoprotein receptor-1 (LOX-1)

氧化型低密度脂蛋白受体-1是一个动脉粥样硬化和血管损伤的生物标示物

Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.

Synonyms

• LOX-1
• OLR-1

Human LOX-1, 273 amino acids, MW 30959 Da 10 20 30 40 50 60 MTFDDLKIQT VKDQPDEKSN GKKAKGLQFL YSPWWCLAAA TLGVLCLGLV VTIMVLGMQL 70 80 90 100 110 120 SQVSDLLTQE QANLTHQKKK LEGQISARQQ AEEASQESEN ELKEMIETLA RKLNEKSKEQ 130 140 150 160 170 180 MELHHQNLNL QETLKRVANC SAPCPQDWIW HGENCYLFSS GSFNWEKSQE KCLSLDAKLL 190 200 210 220 230 240 KINSTADLDF IQQAISYSSF PFWMGLSRRN PSYPWLWEDG SPLMPHLFRV RGAVSQTYPS 250 260 270 GTCAYIQRGA VYAENCILAA FSICQKKANL RAQ 273 Swiss-Prot entry P78380; Gene ID: 4973. Homodimer; disulfide-linked. May form a hexamer composed of 3 homodimers. Interacts with HSP70. Expressed at high level in endothelial cells and vascular-rich organs such as placenta, lung, liver and brain, aortic intima, bone marrow, spinal cord and substantia nigra. Also expressed at the surface of dendritic cells. Widely expressed at intermediate and low level. By inflammatory cytokines such as TNF-alpha, IFN-gamma, IL-6 and by pathological conditions such as hyperlipidemia, hypertension and diabetes mellitus. Up-regulated in atherosclerotic lesions, by oxLDL, reactive oxygen species and fluid shear stress, suggesting that it may participate in amplification of oxLDL-induced vascular dysfunction. Important interactions between two major determinants of atherosclerosis, angiotensin II and dyslipidemia. Ox-LDL via LOX-1 upregulates Ang II type 1 receptor expression and Ang II transcriptionally upregulates the expression of LOX-1. Shear stress, endothelin and TNF- also upregulate LOX-1. Activation of both AT1 and LOX-1 receptors via redox signaling leads to cell dysfunction culminating in apoptosis and cell injury, monocyte adhesion and activation and eventually atherosclerosis. Jawahar L. Mehta。 Cardiovascular Research 2006 69(1):36-45 Impact of LOX-1 expression on atherosclerosis. The degree of LOX-1 expression is a critical determinant of reactive oxygen species (ROS) formation, inflammation, endothelial dysfunction, atherosclerosis, and corresponding marker genes. Henning Morawietz Circulation Research. 2007;100:1534. 试剂盒名称 人氧化型低密度脂蛋白受体-1酶联试剂盒 用途 动脉粥样硬化和血管损伤标示物 产品号 SK00006-01 范围 31-2000 pg/mL 样本体积 100 ul， 稀释2倍 样本类型 血清或细胞培养液 样本服务 样本数目80起 订货联系 010-81786624

产品名称	目录号	规格	价格
人氧化型低密度脂蛋白受体酶联试剂盒	SK00006-01	96 T	询价
人氧化型低密度脂蛋白受体酶联试剂盒	SK00006-02	192 T	询价
小鼠氧化型低密度脂蛋白受体酶联试剂盒	SK00006-03	96 T	询价
人氧化型低密度脂蛋白受体单克隆抗体	A00006-01	100 ug	询价
人氧化型低密度脂蛋白受体多克隆抗体	A00006-02	100 ug	询价

 

订货电子信箱：Info@Adipobiotech.com

订货电话号码: 010-81786624; 010-81786244

Immunohistochemistry of untreated (a to c) and pravastatin-treated (a' to c') WHHL rabbits. Cryosections of the aortic arch with advanced atherosclerotic lesions were used. Red staining represents the localization of spindle-shaped SMCs in the media and in the fibrous cap of the lesion (a and a', arrowheads) and of round Ms in the shoulder region of the lesion (b and b', arrows). LOX-1 protein was found in spindle-shaped cells corresponding to SMC staining (c and c', arrowheads) and in round cells corresponding to M staining (c and c', arrows). The LOX-1 protein distribution in pravastatin-treated WHHL rabbits appeared unchanged compared with untreated WHHL rabbits. Green staining is autofluorescence from collagen and elastin in the media (M), blue staining is caused by nuclei after incubation with Hoechst dye 33258. I indicates intima. Bar, 100 μm.