Antibody for Metabolic Syndrome Research
Insulin Rabbit MAb Price: ¥2856		Insulin Rabbit PAb Price: ¥2856		C Peptide RPAb Price: ¥2856		Glucagon RPAb Price: ¥2856
Insulin Mice MAb Price: ¥700

C-Peptide Antibody (IHC Specific) CS4593

Applications Key:  IHC-P=Immunohistochemistry (Paraffin)
Reactivity Key:  H=Human  M=Mouse  R=Rat
Species enclosed in parentheses are predicted to react based on 100% sequence homology. Species cross-reactivity is determined by Western blot.

Specificity / Sensitivity

C-peptide Antibody detects endogenous levels of total C-peptide protein.

Source / Purification

Polyclonal antibodies are produced by immunizing rabbits with a synthetic peptide (KLH-coupled) derived from the sequence of human C-peptide. Antibodies are purified by protein A and peptide affinity chromatography.

IHC-P (paraffin)

Immunohistochemical analysis of paraffin-embedded human pancreas, showing staining of β-cells, using C-Peptide Antibody.

IHC-P (paraffin)

Immunohistochemical analysis of paraffin-embedded mouse pancreas, showing staining of β-cells, using C-Peptide Antibody.

IHC-P (paraffin)

Immunohistochemical analysis of paraffin-embedded rat pancreas showing staining of β-cells using C-Peptide Antibody.

Background

Glucose homeostasis is regulated by hormones. Elevation of blood glucose levels during feeding stimulates insulin release from pancreatic β-cells through a glucose sensing pathway (1). Proinsulin, the insulin precursor molecule, is processed prior to its secretion. Insulin is composed of A-peptide and B-peptide which are joined by a disulfide bond. The center one-third of the molecule is cleaved and released as C-peptide, which has a longer half-life than insulin (2).

1. Straub, S.G. and Sharp, G.W. (2002) Diabetes Metab. Res. Rev. 18, 451-463.
2. Polonsky, K.S. and Rubenstein, A.H. (1984) Diabetes 33, 486-494.