ANGPTL4 ELISA, Protein, Antibody,免疫试剂盒

北京爱迪博生物科技有限公司

www.Adipobiotech.com

Angiopoietin-like protein 4 (ANGPTL4)血管生成素相关蛋白4是一个分泌型糖蛋白调节血糖稳态、脂肪代谢和血管的增生

血管生成素相关蛋白4是一种循环型糖基化蛋白质激素，可以不仅调节糖代谢稳态，脂肪代谢和胰岛素抵抗；还可以作为一种内皮细胞调亡的生存因子，参与抑制血管再生和增生，以及肿瘤细胞的迁移调控。缺氧可以增加血管生成素相关蛋白4的基因表达。血管生成素相关蛋白4基因敲除的动物，有严重的高血糖。二型糖尿病血管生成素相关蛋白4的表达量明显降低。血管生成素相关蛋白4过表达降低血糖水平和糖耐量。血管生成素相关蛋白4可以抑制肿瘤的迁移。

Angiopoietin-related protein 4 precursor:Size: 406 amino acids; 45214 Da

Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorgenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation. Expressed at high levels in the placenta, heart, liver, muscle, pancreas and lung but expressed poorly in the brain and kidney. Found to be highly expressed in the early stages of collagen-induced arthritis . Serum levels of ANGPTL4 are significantly lower in patients with diabetes type 2 than those in healthy subjects, suggesting that decreased ANGPTL4 could be a causative factor of this disease. Produced in ischemic tissues in conditions such as critical leg ischemia. In tumors, ANGPTL4 could be produced in the hypoxic areas surrounding necrotic regions. High levels could be produced in tumor cells of conventional renal cell carcinoma. This molecule therefore seems to be a marker of conventional renal cell carcinoma.

        10         20         30         40         50         60   
MSGAPTAGAA LMLCAATAVL LSAQGGPVQS KSPRFASWDE MNVLAHGLLQ LGQGLREHAE     
        70         80         90        100        110        120   
RTRSQLSALE RRLSACGSAC QGTEGSTDLP LAPESRVDPE VLHSLQTQLK AQNSRIQQLF    
       130        140        150        160        170        180   
HKVAQQQRHL EKQHLRIQHL QSQFGLLDHK HLDHEVAKPA RRKRLPEMAQ PVDPAHNVSR    
       190        200        210        220        230        240   
LHRLPRDCQE LFQVGERQSG LFEIQPQGSP PFLVNCKMTS DGGWTVIQRR HDGSVDFNRP    
       250        260        270        280        290        300   
WEAYKAGFGD PHGEFWLGLE KVHSITGDRN SRLAVQLRDW DGNAELLQFS VHLGGEDTAY   
       310        320        330        340        350        360   
SLQLTAPVAG QLGATTVPPS GLSVPFSTWD QDHDLRRDKN CAKSLSGGWW FGTCSHSNLN   
       370        380        390        400   
GQYFRSIPQQ RQKLKKGIFW KTWRGRYYPL QATTMLIQPM AAEAAS 406

但白质印迹检测大鼠脂肪组织血管生成素相关蛋白4的表达。还原电泳条件。抗体稀释度1:500. 抗体说明书A00309-02-100

免疫组化检测人胎盘组织血管生成素相关蛋白4，福尔马林固定石蜡包埋，抗原修复。抗体稀释度1：200。抗体说明书A00309-02-100

A00309-01-50

A00309-06-100

Aimin Xu， et al. Proc Natl Acad Sci U S A. 2005 April 26; 102(17): 6086–6091.

试剂盒名称	目录号	规格	价格
Human ANGPTL ELISA Kit	SK00309-02	96T	询价
抗人血管生成素相关蛋白4小鼠抗体	A00309-01	50 ul	1400
Mouse Anti- human ANGPTL4 Antibody	A00309-01-50	50 ul	1600
Mouse Anti- human ANGPTL4 Antibody	A00309-01-25	25 ul	800
Rabbit Anti- human ANGPTL4 Antibody	A00309-02-100	100 ul	2000
Rabbit Anti- human ANGPTL4 Antibody	A00309-02-50	50 ul	1300
ANGPTL4 (Human), recombiant	00309-01-50	50 ug	1500
ANGPTL4 (Human), recombiant	00309-01-100	100 ug	2600
ANGPTL4 (Human), recombiant	00309-01-1000	1 mg	询价
人血管生成素相关蛋白4重组蛋白	00309-01-50	50 ug	1500
人血管生成素相关蛋白4重组蛋白	00309-01-100	100 ug	2600
人血管生成素相关蛋白4重组蛋白	00309-01-1000	1 mg	询价
大鼠血管生成素相关蛋白4重组蛋白	00309-06-100	100 ug	2600
Rabbit Anti- rat ANGPTL4 Antibody	A00309-06-100	100 ul	2000
Rabbit Anti- rat ANGPTL4 Antibody	A00309-06- 50	50 ul	1300

订货电子信箱：Info@Adipobiotech.com

订货电话号码: 010-81786624; 010-81786424


	血管生成素-2 (ANG-2)