PD 173074, Selective FGFR1 and FGFR3 inhibitor

• MW 523.67
• 分子式 C₂₈H₄₁N₇O₃
• _溶解度 Soluble to 100 mM in DMSO and to 100 mM in ethanol
• 纯度 >98 %
• 储存 Store at +4°C
• CAS 号码 219580-11-7
• 化学名称 N-[2-[[4-(Diethylamino)butyl]amino]-6-(3,5-dimethoxyphe nyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl) urea

Biological Activity

Selective FGFR1 and FGFR3 inhibitor (IC₅₀ values are 5, 21.5, ~100, 17600 and 19800 nM for FGFR3, FGFR1, VEGFR2, PDGFR and c-Src respectively, and > 50000 nM for EGFR, InsR, MEK and PKC). Inhibits VEGF- and FGF-induced angiogenesis in the mouse cornea model of angiogenesis.

Mohammadi et al (1998) Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain. EMBO J. 17 5896.
Trudel et al (2004) Inhibition of fibroblast growth factor receptor 3 induces differentiation and apoptosis in t(4;14) myeloma. Neoplasia 103 3521.
Buchler et al (2007) Target therapy using small molecule inhibitor against angiogenic receptors in pancreatic cancer. Neoplasia 9 119.