sRAGE多抗

Homozygous RAGE null mice display decreased neointimal expansion on acute femoral artery endothelial denudation. Homozygous RAGE null mice and wild-type littermates were subjected to femoral artery guide wire injury. Intima/media ratio was determined on day 28 after injury (A). Van Gieson’s elastic stain was performed on a representative femoral artery section from a wild-type mouse (B) and a RAGE null mouse (C). Scale bar=50 μm. Shi Fang Yan et al. Circulation Research. 2003;93:1159.

Immunohistochemistry (x5) (A) and Western blot (B) for RAGE in diabetic or nondiabetic plaques, and relationship between glycemic control and RAGE expression in diabetic plaques (C). Note the immunohistochemistry at high magnification (x63) (A, box) showing prevalent RAGE localization in perivascular macrophages in diabetic plaques. These results are typical of 30 diabetic and 30 nondiabetic plaques. Circulation. 2003;108:1070

Confocal microscopy showed staining for RAGE (green staining) on plaque-derived macrophages, concomitant (red staining) with CD68, COX-2, MMP-2, and MMP-9 expression. These results are typical of 30 diabetic and 30 nondiabetic plaques.