Human Chemerin Recombiant is an adipokine related to metabolic syndrome
The role of chemerin and CMKLR1 in adipose tissue biology. Chemerin and the cognate receptor CMKLR1 are highly expressed in adipocytes (step 1). Chemerin is secreted either in the active form or rapidly activated by extracellular proteolytic processing (step 2). Our findings demonstrate that chemerin and CMKLR1 are required for optimal differentiation (step 3) and that both genes have modulatory effects on the expression of adipocyte genes involved in lipid and glucose metabolism (step 4). Furthermore, secreted chemerin may have a role in mediating recruitment (step 5) of CMKLR1-expressing cells (e.g. macrophages) to adipose tissue. The activation of intracellular ERK1/2 signaling (step 6) upon treatment of adipocytes with chemerin provides evidence for autocrine/paracrine action and is consistent with activation of CMKLR1. However, the presence of additional receptors or additional endogenous ligands for CMKLR1 cannot be ruled out at present. Given our findings in adipocytes, altering chemerin and CMKLR1 may have consequences for alterations in systemic metabolism and lipid homeostasis (step 7).
Goralski KB, et al. J Biol Chem. 2007 Sep 21;282(38):28175-88. Epub 2007 Jul 16.
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